Molecular weight (DA)
32kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 160-240
Specificity
ATP4B Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008],
Function
similarity:Belongs to the X(+)/potassium ATPases subunit beta family.,subunit:Composed of two subunits: alpha (catalytic) and beta.,
Protein name
Potassium-transporting ATPase subunit beta (Gastric H(+)/K(+) ATPase subunit beta) (Proton pump beta chain)
Fields
>>Oxidative phosphorylation;>>Metabolic pathways;>>Collecting duct acid secretion;>>Gastric acid secretion
Human protein sequence Database
P51164
Mouse protein sequence database
P50992
Rat protein sequence database
P18598
Cellular localization
Apical cell membrane ; Single-pass type II membrane protein . Cell membrane ; Single-pass type II membrane protein . Localized in the apical canalicular membrane of parietal cells. .
Tissue expression
Colon,Liver,
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