Molecular weight (DA)
113kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 800-880
Specificity
ATP4A Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).,function:Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.,similarity:Belongs to the cation transport ATPase (P-type) family.,similarity:Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.,subunit:Composed of two subunits: alpha (catalytic) and beta.,tissue specificity:Found in gastric mucosa.,
Protein name
Potassium-transporting ATPase alpha chain 1 (EC 3.6.3.10) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)
Fields
>>Oxidative phosphorylation;>>Metabolic pathways;>>Collecting duct acid secretion;>>Gastric acid secretion
Human protein sequence Database
P20648
Mouse protein sequence database
Q64436
Rat protein sequence database
P09626
Cellular localization
Apical cell membrane ; Multi-pass membrane protein . Localized in the apical canalicular membrane of parietal cells (PubMed:24188822). Localized in the apical canalicular membrane of parietal cells (PubMed:24188822). .
Tissue expression
Expressed in gastric parietal cells (at protein level).
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