Molecular weight (DA)
69kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 580-660
Specificity
NOG1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008],
Function
function:Involved in the biogenesis of the 60S ribosomal subunit.,similarity:Belongs to the GTP1/OBG family. NOG subfamily.,
Gene Name
GTPBP4 CRFG NOG1
Protein name
Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)
Fields
>>Ribosome biogenesis in eukaryotes
Human protein sequence Database
Q9BZE4
Mouse protein sequence database
Q99ME9
Rat protein sequence database
Q99P77
Cellular localization
Nucleus, nucleolus .
Tissue expression
Cervix carcinoma,Epithelium,Kidney,Liver,Uterus,
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