Molecular weight (DA)
229kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 230-310
Specificity
NU214 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
nucleoporin 214(NUP214) Homo sapiens The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015],
Function
disease:A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene.,disease:A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.,disease:Defects in NUP214 may be a cause of breast cancer.,domain:Contains FG repeats.,function:May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.,PTM:Probably glycosylated as it reacts with wheat germ agglutinin (WGA).,subcellular location:Cytoplasmic filaments.,subunit:Homodimer. Interacts with DDX19, NUP88, XPO1 and XPO5.,tissue specificity:Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissu
Gene Name
NUP214 CAIN CAN KIAA0023
Protein name
Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN)
Fields
>>Nucleocytoplasmic transport;>>Amyotrophic lateral sclerosis
Human protein sequence Database
P35658
Mouse protein sequence database
Q80U93
Rat protein sequence database
Cellular localization
Nucleus, nuclear pore complex . Cytoplasmic side of the nuclear pore complex. .
Tissue expression
Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车