Molecular weight (DA)
127kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 830-910
Specificity
NU133 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
nucleoporin 133(NUP133) Homo sapiens The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008],
Function
function:Involved in poly(A)+ RNA transport.,similarity:Belongs to the nucleoporin Nup133 family.,subcellular location:Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores.,subunit:Forms part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus.,
Protein name
Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133)
Fields
>>Nucleocytoplasmic transport;>>Amyotrophic lateral sclerosis
Human protein sequence Database
Q8WUM0
Mouse protein sequence database
Q8R0G9
Rat protein sequence database
Cellular localization
Nucleus, nuclear pore complex . Chromosome, centromere, kinetochore . Located on both the cytoplasmic and nuclear sides of the nuclear pore (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). .
Tissue expression
Widely expressed in fetal and adult tissues. Expressed in the brain and kidney.
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