Molecular weight (DA)
13kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 20-100
Specificity
NMB Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],
Function
function:Stimulates smooth muscle contraction in a manner similar to that of bombesin.,similarity:Belongs to the bombesin/neuromedin-B/ranatensin family.,
Protein name
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P08949
Mouse protein sequence database
Q9CR53
Rat protein sequence database
Cellular localization
Secreted . Cell projection, neuron projection . In neurons of the retrotrapezoid nucleus//parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex. .
Tissue expression
Brain,Hypothalamus,Ovary,
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