Molecular weight (DA)
132kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 140-220
Specificity
CHL1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011],
Function
disease:The deletion of 1 copy of the CHL1 may be responsible for mental defects in patients with 3p- syndrome. 3p- syndrome results from deletion of a terminal segment of the short arm of one chromosome 3 and is characterized by multiple congenital anomalies and mental retardation.,domain:The DGEA motif seems to be a recognition site for integrin.,domain:The FIG[AQ]Y motif seems to be an ankyrin recruitment region.,function:Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneratio
Protein name
Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein]
Human protein sequence Database
O00533
Mouse protein sequence database
P70232
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Soluble forms produced by cleavage/shedding also exist. .; [Processed neural cell adhesion molecule L1-like protein]: Secreted, extracellular space, extracellular matrix .
Tissue expression
Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.
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