Molecular weight (DA)
25kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 10-90
Specificity
LIN7A Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain. [provided by RefSeq, May 2016],
Function
domain:The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.,domain:The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.,domain:The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.,function:Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynapt
Gene Name
LIN7A MALS1 VELI1
Protein name
Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1)
Human protein sequence Database
O14910
Mouse protein sequence database
Q8JZS0
Rat protein sequence database
Q9Z250
Cellular localization
Cell membrane ; Peripheral membrane protein . Basolateral cell membrane ; Peripheral membrane protein . Cell junction . Cell junction, synapse, postsynaptic density membrane ; Peripheral membrane protein . Cell junction, tight junction . Mainly basolateral in renal epithelial cells. .
Tissue expression
Expressed in brain, testis, kidney, placenta and liver.
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