Molecular weight (DA)
73kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
HAP1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
Function
alternative products:Additional isoforms seem to exist,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat.,similarity:Contains 1 HAP1 N-terminal domain.,tissue specificity:Predominantly expressed in brain. Selectively expressed in neurons.,
Protein name
Huntingtin-associated protein 1 (HAP-1) (Neuroan 1)
Fields
>>GABAergic synapse;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
P54257
Mouse protein sequence database
O35668
Rat protein sequence database
P54256
Cellular localization
Cytoplasm . Cell projection, axon . Cell junction, synapse, presynapse . Cytoplasm, cytoskeleton . Cell projection, dendritic spine . Cell projection, dendrite . Lysosome . Endoplasmic reticulum . Mitochondrion . Nucleus . Cytoplasmic vesicle, autophagosome . Early endosome . Cell projection, growth cone . Cell projection, neuron projection . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . Localizes to large nonmembrane-bound cytoplasmic bodies found in various types of neurons, called stigmoid bodies (STBs). Localization to neuronal processes and neurite tips is decreased by YWHAZ. In the nucleus localizes to nuclear rods. .
Tissue expression
Predominantly expressed in brain. Selectively expressed in neurons.
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