Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TRI63 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012],
Function
caution:It is uncertain whether Met-1 or Met-14 is the initiator.,developmental stage:Expressed throughout all developmental stages.,domain:The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity.,function:E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.,pathway:Protein modification; protein ubiquitination.,sequence caution:Sequencing errors.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 COS domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Localizes to the M- and Z-lines in s
Gene Name
TRIM63 IRF MURF1 RNF28 SMRZ
Protein name
E3 ubiquitin-protein ligase TRIM63 (EC 6.3.2.-) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (Striated muscle RING zinc finger protein)
Human protein sequence Database
Q969Q1
Mouse protein sequence database
Q38HM4
Rat protein sequence database
Q91Z63
Cellular localization
Cytoplasm. Nucleus . Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. .
Tissue expression
Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.
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