Molecular weight (DA)
73kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
TRAF7 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
TNF receptor associated factor 7(TRAF7) Homo sapiens Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004],
Function
function:E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated by MAP3K3.,PTM:Ubiquitinates itself upon phosphorylation.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 TRAF-type zinc finger.,similarity:Contains 7 WD repeats.,subcellular location:Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.,subunit:Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.,tissue specificity:Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.,
Gene Name
TRAF7 RFWD1 RNF119
Protein name
E3 ubiquitin-protein ligase TRAF7 (EC 6.3.2.-) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (TNF receptor-associated factor 7)
Human protein sequence Database
Q6Q0C0
Mouse protein sequence database
Q922B6
Rat protein sequence database
Cellular localization
Cytoplasmic vesicle . Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
Tissue expression
Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
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