Molecular weight (DA)
235kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DOCK7 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],
Function
domain:The DHR-2 domain mediates GEF activity.,function:Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization.,similarity:Belongs to the DOCK family.,similarity:Contains 1 DHR-1 (CZH-1) domain.,similarity:Contains 1 DHR-2 (CZH-2) domain.,subcellular location:Enriched in the developing axons of hippocampal neurons.,subunit:Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3.,tissue specificity:Widely expressed.,
Protein name
Dedicator of cytokinesis protein 7
Human protein sequence Database
Q96N67
Mouse protein sequence database
Q8R1A4
Rat protein sequence database
Cellular localization
Cell projection, axon . Enriched in the developing axons of hippocampal neurons.
Tissue expression
Widely expressed.
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