Molecular weight (DA)
61kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
5NTC Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011],
Function
catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Binds 1 magnesium ion per subunit.,disease:Aberration of this enzyme may be related to the urate production in hyperuricemia and gout.,enzyme regulation:Allosterically activated by various compounds, including ATP.,function:May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.,similarity:Belongs to the 5'(3')-deoxyribonucleotidase family.,subunit:Homotetramer.,
Gene Name
NT5C2 NT5B NT5CP PNT5
Protein name
Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (Cytosolic 5'-nucleotidase II)
Fields
>>Purine metabolism;>>Pyrimidine metabolism;>>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Nucleotide metabolism
Human protein sequence Database
P49902
Mouse protein sequence database
Q3V1L4
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol .
Tissue expression
Widely expressed.
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