Molecular weight (DA)
164kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CNDD3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
non-SMC condensin II complex subunit D3(NCAPD3) Homo sapiens Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008],
Function
function:Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.,similarity:Contains 4 HEAT repeats.,subunit:Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.,
Gene Name
NCAPD3 CAPD3 KIAA0056
Protein name
Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3)
Human protein sequence Database
P42695
Mouse protein sequence database
Q6ZQK0
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Bone marrow,Brain,Epithelium,Eye,Placenta,
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