Molecular weight (DA)
59kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CCDC8 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3). [provided by RefSeq, Dec 2011],
Function
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,
Protein name
Coiled-coil domain-containing protein 8
Human protein sequence Database
Q9H0W5
Mouse protein sequence database
D3YZV8
Rat protein sequence database
P62521
Cellular localization
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
Tissue expression
Widely expressed with low levels in spleen, skeletal muscle, small intestine, kidney and liver.
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