Molecular weight (DA)
214kD
Immunogen
Synthesized peptide derived from part region of human protein. AA range 25-75
Specificity
CHD5 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012],
Function
function:May play a role in the development of the nervous system and the pathogenesis of neural tumors.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,similarity:Contains 2 PHD-type zinc fingers.,tissue specificity:Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland.,
Protein name
Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5)
Human protein sequence Database
Q8TDI0
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus . Associates with heterochromatin. .
Tissue expression
Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland and detected in testis.
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