Molecular weight (DA)
73kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CAN13 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012],
Function
caution:It is unlikely that this protein binds calcium as none of the 2 EF-hand domains seem to contain a canonical calcium-binding site.,function:Probable non-lysosomal thiol-protease.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 2 EF-hand domains.,tissue specificity:Weakly expressed in lung and testis. Weakly or not expressed in other tissues.,
Protein name
Calpain-13 (EC 3.4.22.-) (Calcium-activated neutral proteinase 13) (CANP 13)
Human protein sequence Database
Q6MZZ7
Mouse protein sequence database
Q3UW68
Rat protein sequence database
Q5BK10
Cellular localization
intracellular,cytoplasm,
Tissue expression
Weakly expressed in lung and testis. Weakly or not expressed in other tissues.
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