Molecular weight (DA)
80kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 510-590
Specificity
ABCB8 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
Function
similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.,similarity:Contains 1 ABC transmembrane type-1 domain.,similarity:Contains 1 ABC transporter domain.,subunit:Monomer .,tissue specificity:Ubiquitous.,
Protein name
ATP-binding cassette sub-family B member 8, mitochondrial (Mitochondrial ATP-binding cassette 1) (M-ABC1)
Fields
>>ABC transporters
Human protein sequence Database
Q9NUT2
Mouse protein sequence database
Q9CXJ4
Rat protein sequence database
Q5RKI8
Cellular localization
Mitochondrion inner membrane ; Multi-pass membrane protein .
Tissue expression
Ubiquitous.
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