Molecular weight (DA)
32kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 160-240
Specificity
AQP9 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability. This protein may also facilitate the uptake of glycerol in hepatic tissue . The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
Function
domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,function:Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea but not to glycerol.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family.,tissue specificity:Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen.,
Protein name
Aquaporin-9 (AQP-9) (Aquaglyceroporin-9) (Small solute channel 1)
Fields
>>Neutrophil extracellular trap formation;>>Bile secretion
Human protein sequence Database
O43315
Mouse protein sequence database
Q9JJJ3
Rat protein sequence database
P56627
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen.
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