Molecular weight (DA)
119kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 710-790
Specificity
AMOT Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Function
domain:The angiostatin binding domain (871-1005) allows the binding to angiostatin.,domain:The coiled coil domain interacts directly with the BAR domain of ARHGAP17.,function:Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.,miscellaneous:'Motus' means motility in Latin.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the angiomotin family.,subcellular location:Localized on the cell surface. May act as a transmembrane protein.,subunit:Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3.
Fields
>>Hippo signaling pathway;>>Tight junction
Human protein sequence Database
Q4VCS5
Mouse protein sequence database
Q8VHG2
Rat protein sequence database
Cellular localization
Cell junction, tight junction . Localized on the cell surface. May act as a transmembrane protein.
Tissue expression
Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
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