Molecular weight (DA)
74kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 270-350
Specificity
ACOX2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. [provided by RefSeq, Mar 2009],
Function
catalytic activity:(25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oyl-CoA + H(2)O + acceptor = (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA + reduced acceptor.,cofactor:FAD.,disease:Absent in patients suffering from Zellweger syndrome.,function:Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids.,similarity:Belongs to the acyl-CoA oxidase family.,subunit:Heterodimer.,tissue specificity:Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney.,
Protein name
Peroxisomal acyl-coenzyme A oxidase 2 (EC 1.17.99.3) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase)
Fields
>>Primary bile acid biosynthesis;>>Metabolic pathways;>>PPAR signaling pathway;>>Peroxisome
Human protein sequence Database
Q99424
Mouse protein sequence database
Q9QXD1
Rat protein sequence database
P97562
Cellular localization
Peroxisome .
Tissue expression
Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney.
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