Molecular weight (DA)
30kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 160-240
Specificity
HUS1B Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008],
Function
similarity:Belongs to the HUS1 family.,subunit:Interacts with RAD1 and RAD9B.,tissue specificity:Expressed strongly in testis, less in spleen, thymus, prostate, colon and leukocytes.,
Protein name
Checkpoint protein HUS1B (hHUS1B)
Human protein sequence Database
Q8NHY5
Mouse protein sequence database
Q8K572
Rat protein sequence database
Cellular localization
nucleolus,checkpoint clamp complex,site of double-strand break,
Tissue expression
Expressed strongly in testis, less in spleen, thymus, prostate, colon and leukocytes.
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