Molecular weight (DA)
149kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 350-430
Specificity
TNIK Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in cytoskeletal regulation.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CNH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with TRAF2 and NCK.,tissue specificity:Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle.,
Protein name
TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)
Human protein sequence Database
Q9UKE5
Mouse protein sequence database
P83510
Rat protein sequence database
Cellular localization
Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Tissue expression
Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
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