Molecular weight (DA)
65kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 370-450
Specificity
MYLK2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.,disease:Defects in MYLK2 are a cause of cardiomyopathy familial hypertrophic (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,function:Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr pr
Protein name
Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18)
Fields
>>Calcium signaling pathway;>>cGMP-PKG signaling pathway;>>Vascular smooth muscle contraction;>>Apelin signaling pathway;>>Focal adhesion;>>Platelet activation;>>Regulation of actin cytoskeleton;>>Oxytocin signaling pathway;>>Gastric acid secretion
Human protein sequence Database
Q9H1R3
Mouse protein sequence database
Q8VCR8
Rat protein sequence database
P20689
Cellular localization
Cytoplasm. Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
Tissue expression
Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
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