Molecular weight (DA)
13kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 10-90
Specificity
LTOR2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009],
Function
disease:Defects in ROBLD3 are the cause of immunodeficiency due to defect in MAPBP-interacting protein [MIM:610798]. This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency.,function:Adapter protein that enhances the efficiency of the MAP kinase cascade. Facilitates the activation of MAPK2.,online information:ROBLD3 mutation db,similarity:Belongs to the GAMAD family.,subunit:Heterodimer with MAP2K1IP1. Interacts with MAPK1 and MAP2K1.,
Gene Name
LAMTOR2 MAPBPIP ROBLD3 HSPC003
Protein name
Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated
Fields
>>mTOR signaling pathway
Human protein sequence Database
Q9Y2Q5
Mouse protein sequence database
Q9JHS3
Rat protein sequence database
Cellular localization
Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
Tissue expression
Lung,Umbilical cord blood,
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