Molecular weight (DA)
46kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 330-410
Specificity
AGK Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012],
Function
catalytic activity:ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.,catalytic activity:ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate.,cofactor:Magnesium.,function:Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.,miscellaneous:Overexpressed in prostate cancer, suggesting that it may play a role in initiation and progression of prostate cancer, processes in which LPA plays key roles.,pathway:Lipid metabolism; glycerolipid metabolism.,similarity:Contains 1 DAGKc domain.,tissue specificity:Highly expressed in muscle, heart, kidney and br
Protein name
Acylglycerol kinase, mitochondrial (hAGK) (EC 2.7.1.107) (EC 2.7.1.94) (Multiple substrate lipid kinase) (HsMuLK) (MuLK) (Multi-substrate lipid kinase)
Fields
>>Glycerolipid metabolism;>>Metabolic pathways
Human protein sequence Database
Q53H12
Mouse protein sequence database
Q9ESW4
Rat protein sequence database
Cellular localization
Mitochondrion inner membrane ; Peripheral membrane protein . Mitochondrion intermembrane space . Localizes in the mitochondrion intermembrane space, where it associates with the inner membrane (PubMed:28712724). It is unclear whether the N-terminal hydrophobic region forms a transmembrane region or associates with the membrane without crossing it (PubMed:28712724, PubMed:28712726). .
Tissue expression
Highly expressed in muscle, heart, kidney and brain.
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