Molecular weight (DA)
147kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 1120-1200
Specificity
ACINU Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011],
Function
function:Induces apoptotic chromatin condensation after activation by CASP3.,PTM:Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.,similarity:Contains 1 SAP domain.,subunit:Interacts with API5.,tissue specificity:Ubiquitous.,
Gene Name
ACIN1 ACINUS KIAA0670
Protein name
Apoptotic chromatin condensation inducer in the nucleus (Acinus)
Fields
>>Nucleocytoplasmic transport;>>mRNA surveillance pathway;>>Spliceosome
Human protein sequence Database
Q9UKV3
Mouse protein sequence database
Q9JIX8
Rat protein sequence database
Cellular localization
Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.
Tissue expression
Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.
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