Molecular weight (DA)
29kD
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human DKK1. AA range:181-230
Specificity
Dkk-1 Polyclonal Antibody detects endogenous levels of Dkk-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008],
Function
function:Inhibitor of Wnt signaling pathway.,similarity:Belongs to the dickkopf family.,tissue specificity:Placenta.,
Protein name
Dickkopf-related protein 1
Other name
DKK1; Dickkopf-related protein 1; Dickkopf-1; Dkk-1; hDkk-1; SK
Fields
>>Wnt signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
O94907
Mouse protein sequence database
O54908
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Placenta.
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