Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SEPT8. AA range:170-219
Specificity
Septin 8 Polyclonal Antibody detects endogenous levels of Septin 8 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
septin 8(SEPT8) Homo sapiens This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],
Function
similarity:Belongs to the septin family.,subunit:Interacts with SEPT5.,tissue specificity:Expressed in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen, whereas isoforms 1 and 3 are highly expressed in these areas. In prostate, testis and ovary, isoform 2 is highly expressed, while isoforms 1 and 3 found at low levels.,
Other name
SEPT8; KIAA0202; Septin-8
Fields
>>Bacterial invasion of epithelial cells;>>Shigellosis
Human protein sequence Database
Q92599
Mouse protein sequence database
Q8CHH9
Rat protein sequence database
B0BNF1
Cellular localization
Cytoplasm . Cytoplasm, cytoskeleton . Cell junction, synapse . Cell projection, axon . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Cell junction, synapse, presynapse . Expressed in axons of immature neurons, localizes to synapses in mature neurons (By similarity). In platelets, found in areas surrounding alpha-granules (PubMed:15116257). .
Tissue expression
Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary.
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