Molecular weight (DA)
20kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RGS5. AA range:89-138
Specificity
RGS5 Polyclonal Antibody detects endogenous levels of RGS5 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011],
Function
function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.,similarity:Contains 1 RGS domain.,
Protein name
Regulator of G-protein signaling 5
Other name
RGS5; Regulator of G-protein signaling 5; RGS5
Human protein sequence Database
O15539
Mouse protein sequence database
O08850
Rat protein sequence database
P49800
Cellular localization
[Isoform 1]: Cytoplasm . Membrane .; [Isoform 2]: Cytoplasm .
Tissue expression
Aorta,Brain,Human cervix,Liver,Neuroblastoma,Normal aorta,
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