Molecular weight (DA)
22kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MRPS17. AA range:11-60
Specificity
MRP-S17 Polyclonal Antibody detects endogenous levels of MRP-S17 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found
Function
similarity:Belongs to the ribosomal protein S17P family.,subunit:Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.,
Protein name
28S ribosomal protein S17 mitochondrial
Other name
MRPS17; RPMS17; HSPC011; 28S ribosomal protein S17; mitochondrial; MRP-S17; S17mt
Human protein sequence Database
Q9Y2R5
Mouse protein sequence database
Q9CQE3
Rat protein sequence database
Cellular localization
Mitochondrion .
Tissue expression
Brain,Epithelium,Kidney,Umbilical cord blood,Uterus,
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