Molecular weight (DA)
22kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MRPL50. AA range:109-158
Specificity
MRP-L50 Polyclonal Antibody detects endogenous levels of MRP-L50 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q. [provided by RefSeq, Jul 2008],
Protein name
39S ribosomal protein L50 mitochondrial
Other name
MRPL50; 39S ribosomal protein L50; mitochondrial; L50mt; MRP-L50
Human protein sequence Database
Q8N5N7
Mouse protein sequence database
Q8VDT9
Rat protein sequence database
Cellular localization
Mitochondrion .
Tissue expression
Carcinoma,Epithelium,Hepatoma,Skin,
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