Molecular weight (DA)
19kD
Immunogen
Synthesized peptide derived from MRP-L49 . at AA range: 10-90
Specificity
MRP-L49 Polyclonal Antibody detects endogenous levels of MRP-L49 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011],
Function
similarity:Belongs to the ribosomal protein L49em family.,tissue specificity:Ubiquitous.,
Protein name
39S ribosomal protein L49 mitochondrial
Other name
MRPL49; C11orf4; NOF1; OK/SW-cl.67; 39S ribosomal protein L49; mitochondrial; L49mt; MRP-L49; Neighbor of FAU; NOF; Protein NOF1
Human protein sequence Database
Q13405
Mouse protein sequence database
Q9CQ40
Rat protein sequence database
Cellular localization
Mitochondrion .
Tissue expression
Ubiquitous.
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