Molecular weight (DA)
162kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MRP7. AA range:835-884
Specificity
MRP7 Polyclonal Antibody detects endogenous levels of MRP7 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010],
Function
function:ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed.,
Protein name
Multidrug resistance-associated protein 7
Other name
ABCC10; MRP7; SIMRP7; Multidrug resistance-associated protein 7; ATP-binding cassette sub-family C member 10
Fields
>>ABC transporters
Human protein sequence Database
Q5T3U5
Mouse protein sequence database
Q8R4P9
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein .
Tissue expression
[Isoform 1]: Specifically expressed in spleen. ; [Isoform 2]: Widely expressed.
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