Immunogen
The antiserum was produced against synthesized peptide derived from human LRRK1. AA range:361-410
Specificity
LRRK1 Polyclonal Antibody detects endogenous levels of LRRK1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium or manganese.,enzyme regulation:Binding of GTP stimulates kinase activity.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 Roc domain.,similarity:Contains 11 LRR (leucine-rich) repeats.,similarity:Contains 4 ANK repeats.,
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium or manganese.,enzyme regulation:Binding of GTP stimulates kinase activity.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 Roc domain.,similarity:Contains 11 LRR (leucine-rich) repeats.,similarity:Contains 4 ANK repeats.,
Protein name
Leucine-rich repeat serine/threonine-protein kinase 1
Other name
LRRK1; KIAA1790; Leucine-rich repeat serine/threonine-protein kinase 1
Human protein sequence Database
Q38SD2
Mouse protein sequence database
Q3UHC2
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Brain,Cervix,Lung,Macrophage,Pancreas,Skin,Spleen,
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