Molecular weight (DA)
85kD
Immunogen
Synthesized peptide derived from Fyb . at AA range: 620-700
Specificity
Fyb Polyclonal Antibody detects endogenous levels of Fyb protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],
Function
function:Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.,PTM:T-cell receptor ligation leads to increased tyrosine phosphorylation.,similarity:Contains 1 SH3 domain.,subunit:Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity). Interacts with FYN, LCP2, SKAP1 and SKAP2.,tissue specificity:Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.,
Protein name
FYN-binding protein
Other name
FYB; SLAP130; FYN-binding protein; Adhesion and degranulation promoting adaptor protein; ADAP; FYB-120/130; p120/p130; FYN-T-binding protein; SLAP-130; SLP-76-associated phosphoprotein
Fields
>>Rap1 signaling pathway;>>Yersinia infection
Human protein sequence Database
O15117
Mouse protein sequence database
O35601
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Cell junction . Colocalizes with TMEM47 at cell-cell contacts in podocytes. .
Tissue expression
Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.
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