Molecular weight (DA)
81kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ES8L2. AA range:1-50
Specificity
Eps8L2 Polyclonal Antibody detects endogenous levels of Eps8L2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008],
Function
function:Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.,similarity:Belongs to the EPS8 family.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.,tissue specificity:Detected in fibroblasts and placenta.,
Protein name
Epidermal growth factor receptor kinase substrate 8-like protein 2
Other name
EPS8L2; EPS8R2; PP13181; Epidermal growth factor receptor kinase substrate 8-like protein 2; EPS8-like protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8-related protein 2
Human protein sequence Database
Q9H6S3
Mouse protein sequence database
Q99K30
Rat protein sequence database
Cellular localization
Cytoplasm . Cell projection, stereocilium . Localizes at the tips of the stereocilia of the inner and outer hair cells. .
Tissue expression
Detected in fibroblasts and placenta.
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