Molecular weight (DA)
80kD
Immunogen
Synthesized peptide derived from Dvl-2 . at AA range: 670-750
Specificity
Dvl-2 Polyclonal Antibody detects endogenous levels of Dvl-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008],
Function
function:May play a role in the signal transduction pathway mediated by multiple Wnt genes.,PTM:Phosphorylated.,similarity:Belongs to the DSH family.,similarity:Contains 1 DEP domain.,similarity:Contains 1 DIX domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts with DIXDC1 and Rac.,
Protein name
Segment polarity protein dishevelled homolog DVL-2
Other name
DVL2; Segment polarity protein dishevelled homolog DVL-2; Dishevelled-2; DSH homolog 2
Fields
>>mTOR signaling pathway;>>Wnt signaling pathway;>>Notch signaling pathway;>>Hippo signaling pathway;>>Signaling pathways regulating pluripotency of stem cells;>>Melanogenesis;>>Cushing syndrome;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Human papillomavirus infection;>>Pathways in cancer;>>Basal cell carcinoma;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer
Human protein sequence Database
O14641
Mouse protein sequence database
Q60838
Rat protein sequence database
Cellular localization
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Cytoplasmic vesicle . Nucleus . Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136). .
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