Molecular weight (DA)
22kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RCAN1. AA range:201-250
Specificity
DSCR 1 Polyclonal Antibody detects endogenous levels of DSCR 1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],
Function
function:Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.,induction:By calcium.,similarity:Belongs to the RCAN family.,tissue specificity:Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.,
Protein name
Calcipressin-1
Other name
RCAN1; ADAPT78; CSP1; DSC1; DSCR1; Calcipressin-1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1
Fields
>>Thyroid hormone signaling pathway;>>Oxytocin signaling pathway;>>Kaposi sarcoma-associated herpesvirus infection
Human protein sequence Database
P53805
Mouse protein sequence database
Q9JHG6
Rat protein sequence database
Q6IN33
Cellular localization
intracellular,nucleus,cytoplasm,
Tissue expression
Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.
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