Molecular weight (DA)
63kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CSGALNACT2. AA range:61-110
Specificity
CsGalNAcT-2 Polyclonal Antibody detects endogenous levels of CsGalNAcT-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome X. [provided by RefSeq, Feb 2016],
Function
catalytic activity:UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan.,function:Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains.,online information:Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2,online information:GlycoGene database,similarity:Belongs to the chondroitin N-acetylgalactosaminyltransferase family.,tissue specificity:Ubiquitous.,
Protein name
Chondroitin sulfate N-acetylgalactosaminyltransferase 2
Other name
CSGALNACT2; CHGN2; GALNACT2; Chondroitin sulfate N-acetylgalactosaminyltransferase 2; Chondroitin beta-1; 4-N-acetylgalactosaminyltransferase 2; Beta4GalNAcT-2; GalNAcT-2
Fields
>>Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate;>>Metabolic pathways
Human protein sequence Database
Q8N6G5
Mouse protein sequence database
Q8C1F4
Rat protein sequence database
Cellular localization
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein .
Tissue expression
Ubiquitous.
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