Immunogen
The antiserum was produced against synthesized peptide derived from human BAI3. AA range:211-260
Specificity
BAI-3 Polyclonal Antibody detects endogenous levels of BAI-3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008],
Function
function:Might be involved in angiogenesis inhibition and suppression of glioblastoma.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 CUB domain.,similarity:Contains 1 GPS domain.,similarity:Contains 4 TSP type-1 domains.,tissue specificity:Strongly expressed in brain. Also detected in heart. Reduced expression is observed in some glioblastoma cell lines.,
Protein name
Brain-specific angiogenesis inhibitor 3
Other name
BAI3; KIAA0550; Brain-specific angiogenesis inhibitor 3
Human protein sequence Database
O60242
Mouse protein sequence database
Q80ZF8
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Strongly expressed in brain. Also detected in heart. Reduced expression in some glioblastoma cell lines.
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