Molecular weight (DA)
38kD
Immunogen
The antiserum was produced against synthesized peptide derived from human AHSA1. AA range:161-210
Specificity
AHA-1 Polyclonal Antibody detects endogenous levels of AHA-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300;ELISA 1:5000-20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic reticulum to Golgi trafficking.,induction:By heat shock and treatment with the HSP90 inhibitor 17-demethoxygeldanamycin (17AAG).,similarity:Belongs to the AHA1 family.,subcellular location:May transiently interact with the endoplasmic reticulum.,subunit:Interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatitis virus glycoprotein (VSV G). Interacts with GCH1.,tissue specificity:Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.,
Function
function:Cochaperone that stimulates HSP90 ATPase activity (By similarity). May affect a step in the endoplasmic reticulum to Golgi trafficking.,induction:By heat shock and treatment with the HSP90 inhibitor 17-demethoxygeldanamycin (17AAG).,similarity:Belongs to the AHA1 family.,subcellular location:May transiently interact with the endoplasmic reticulum.,subunit:Interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatitis virus glycoprotein (VSV G). Interacts with GCH1.,tissue specificity:Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.,
Protein name
Activator of 90 kDa heat shock protein ATPase homolog 1
Other name
AHSA1; C14orf3; HSPC322; Activator of 90 kDa heat shock protein ATPase homolog 1; AHA1; p38
Human protein sequence Database
O95433
Mouse protein sequence database
Q8BK64
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Endoplasmic reticulum . May transiently interact with the endoplasmic reticulum.
Tissue expression
Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.
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