Molecular weight (DA)
47kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ADPGK. AA range:241-290
Specificity
ADP-GK Polyclonal Antibody detects endogenous levels of ADP-GK protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008],
Function
catalytic activity:ADP + D-glucose = AMP + D-glucose 6-phosphate.,cofactor:Binds 1 magnesium ion per subunit.,function:Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency.,pathway:Carbohydrate degradation; glycolysis.,similarity:Belongs to the ADP-dependent glucokinase family.,similarity:Contains 1 ADPK (ADP-dependent kinase) domain.,subunit:Monomer.,
Protein name
ADP-dependent glucokinase
Other name
ADPGK; PSEC0260; ADP-dependent glucokinase; ADP-GK; ADPGK; RbBP-35
Fields
>>Glycolysis / Gluconeogenesis;>>Metabolic pathways;>>Carbon metabolism
Human protein sequence Database
Q9BRR6
Mouse protein sequence database
Q8VDL4
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Brain,Heart,Kidney,Lymph node,Teratocarcinoma,Testis,
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