Molecular weight (DA)
28kD
Immunogen
The antiserum was produced against synthesized peptide derived from human 14-3-3 gamma. AA range:51-100
Specificity
14-3-3 γ Polyclonal Antibody detects endogenous levels of 14-3-3 γ protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008],
Function
function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.,PTM:Phosphorylated by various PKC isozymes.,similarity:Belongs to the 14-3-3 family.,subunit:Homodimer. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm.,tissue specificity:Highly expressed in brain, skeletal muscle, and heart.,
Protein name
14-3-3 protein gamma
Other name
YWHAG; 14-3-3 protein gamma; Protein kinase C inhibitor protein 1; KCIP-1
Fields
>>Cell cycle;>>Oocyte meiosis;>>PI3K-Akt signaling pathway;>>Hippo signaling pathway;>>Hepatitis C;>>Viral carcinogenesis
Human protein sequence Database
P61981
Mouse protein sequence database
P61982
Rat protein sequence database
P61983
Cellular localization
Cytoplasm .
Tissue expression
Highly expressed in brain, skeletal muscle, and heart.
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