Molecular weight (DA)
270kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NCoR1. AA range:51-100
Specificity
N-CoR Polyclonal Antibody detects endogenous levels of N-CoR protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010],
Function
domain:The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity.,domain:The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).,function:Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.,PTM:Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the N-CoR nuclear receptor corepres
Protein name
Nuclear receptor corepressor 1
Other name
NCOR1; KIAA1047; Nuclear receptor corepressor 1; N-CoR; N-CoR1
Fields
>>Endocrine resistance;>>Thyroid hormone signaling pathway;>>Transcriptional misregulation in cancer
Human protein sequence Database
O75376
Mouse protein sequence database
Q60974
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Brain,Colon,Epithelium,Fetal brain,Lung,Ovary,Pancreas,Pooled,Skin,Testis,
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