Molecular weight (DA)
32kD
Immunogen
Synthesized peptide derived from calbindin 2 at AA range: 191-240
Specificity
Calretinin Polyclonal Antibody detects endogenous levels of calbindin 2
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010],
Function
function:Calretinin is a calcium-binding protein which is abundant in auditory neurons.,online information:Calbindin entry,similarity:Belongs to the calbindin family.,similarity:Contains 6 EF-hand domains.,tissue specificity:Brain.,
Other name
Calretinin (CR;29 kDa calbindin)
Human protein sequence Database
P22676
Mouse protein sequence database
Q08331
Rat protein sequence database
P47728
Cellular localization
nucleus,cytoplasm,cytosol,gap junction,neuron projection,terminal bouton,synapse,
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