Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from the Internal region of human TCP-1 α.
Specificity
TCP-1 α Polyclonal Antibody detects endogenous levels of TCP-1 α protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010],
Function
function:Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.,similarity:Belongs to the TCP-1 chaperonin family.,subunit:Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.,
Protein name
T-complex protein 1 subunit alpha
Other name
TCP1; CCT1; CCTA; T-complex protein 1 subunit alpha; TCP-1-alpha; CCT-alpha
Human protein sequence Database
P17987
Mouse protein sequence database
P11983
Rat protein sequence database
P28480
Cellular localization
Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
Tissue expression
Brain,Cajal-Retzius cell,Colon,Epithelium,Platelet,Testis,
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