Molecular weight (DA)
55kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Peripherin. AA range:421-470
Specificity
PRPH Polyclonal Antibody detects endogenous levels of PRPH protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008],
Function
function:Class-III neuronal intermediate filament protein.,online information:Peripherin entry,similarity:Belongs to the intermediate filament family.,
Other name
PRPH; NEF4; PRPH1; Peripherin; Neurofilament 4
Fields
>>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
P41219
Mouse protein sequence database
P15331
Rat protein sequence database
P21807
Cellular localization
Cytoplasm, cytoskeleton . Cell projection, axon . Perikaryon .
Tissue expression
Expressed in the neurons of the outer hair cells in the organ of Corti and to a lesser extent in type I spiral ganglion cells.
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