Molecular weight (DA)
17kD
Immunogen
Synthesized peptide derived from the Internal region of human MYL6.
Specificity
MYL6 Polyclonal Antibody detects endogenous levels of MYL6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
Function
function:Regulatory light chain of myosin. Does not bind calcium.,similarity:Contains 3 EF-hand domains.,subunit:Myosin is an hexamer of 2 heavy chains and 4 light chains.,
Protein name
Myosin light polypeptide 6
Other name
MYL6; Myosin light polypeptide 6; 17 kDa myosin light chain; LC17; Myosin light chain 3; MLC-3; Myosin light chain alkali 3; Myosin light chain A3; Smooth muscle and nonmuscle myosin light chain alkali 6
Fields
>>Vascular smooth muscle contraction;>>Tight junction;>>Oxytocin signaling pathway
Human protein sequence Database
P60660
Mouse protein sequence database
Q60605
Rat protein sequence database
Q64119
Cellular localization
cytosol,brush border,membrane,myosin complex,unconventional myosin complex,extracellular matrix,vesicle,extracellular exosome,
Tissue expression
B-cell lymphoma,Brain,Duodenum,Eye,Lung,Placenta,
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