Molecular weight (DA)
228kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MYH14. AA range:1051-1100
Specificity
MYH14 Polyclonal Antibody detects endogenous levels of MYH14 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
Function
disease:Defects in MYH14 are the cause of non-syndromic sensorineural deafness autosomal dominant type 4 (DFNA4) [MIM:600652]. DFNA4 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,domain:The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.,function:Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.,sequence caution:Translation N-terminally extended.,similarity:Contains 1 IQ domain.,similarity:Contains 1 myosin head-like domain.,subunit:Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light cha
Other name
MYH14; KIAA2034; FP17425; Myosin-14; Myosin heavy chain 14; Myosin heavy chain; non-muscle IIc; Non-muscle myosin heavy chain IIc; NMHC II-C
Fields
>>Vascular smooth muscle contraction;>>Tight junction;>>Regulation of actin cytoskeleton;>>Pathogenic Escherichia coli infection
Human protein sequence Database
Q7Z406
Mouse protein sequence database
Q6URW6
Rat protein sequence database
Cellular localization
stress fiber,cytosol,brush border,membrane,myosin complex,myosin II complex,axon,growth cone,actomyosin,myelin sheath,extracellular exosome,myosin II filament,
Tissue expression
High levels of expression are found in brain (highest in corpus callosum), heart, kidney, liver, lung, small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes.
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